Nathan is getting married and he's left his four friends to plan his bachelor party. But what Z-Bob thinks is a fool-proof plan to a wild night in Vegas, ends up as a chase across Vegas in what would be a weekend they would never forget.

A mysterious killer video tape is circulating around. One look at this tape and you have seven days left to live. News Reporter Cindy Campbell (Faris) witnesses this video tape and tries to work out a way to prevent her death. But this is not the only mystery to appear. Crop circles have been appearing in the local farm of Tom (Sheen) and George (Rex). With help from Aunt Shaneequa (Latifah), Cindy suspects that the aliens may be linked with the killer tape and must now work out both mysteries...